Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis
Sign Up to like & getrecommendations! Published in 2024 at "Oncogenesis"
DOI: 10.1038/s41389-024-00539-w
Abstract: SS18-SSX onco-fusion protein formed through aberrant chromosomal translocation t (X, 18; p11, q11), is the hallmark and plays a critical role in synovial sarcomagenesis. The recent works indicated that both the pathological SS18-SSX tumorigenic fusion… read more here.
Keywords: ss18; synovial sarcomagenesis; ss18 ssx; protein ... See more keywords
The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65850-5
Abstract: Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin… read more here.
Keywords: ssx mediated; mediated transformation; ss18 ssx; synovial sarcoma ... See more keywords
When used together SS18–SSX fusion‐specific and SSX C‐terminus immunohistochemistry are highly specific and sensitive for the diagnosis of synovial sarcoma and can replace FISH or molecular testing in most cases
Sign Up to like & getrecommendations! Published in 2020 at "Histopathology"
DOI: 10.1111/his.14190
Abstract: Synovial sarcoma is defined by recurrent t(X;18)(p11;q11) translocations creating SS18–SSX1, SS18–SSX2 or SS18–SSX4 fusions. Recently, a novel rabbit monoclonal antibody designed to identify these fusions (SS18–SSX, clone E9X9V) was proposed to be highly specific (100%),… read more here.
Keywords: sensitive diagnosis; synovial sarcoma; highly specific; ss18 ssx ... See more keywords
Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.ads7876
Abstract: Cancer-causing aberrations recurrently target the chromatic-regulatory factors, leading to epigenetic dysregulation. Almost all patients with synovial sarcoma (SS) carry a characteristic gene fusion, SS18::SSX, which produces a disease-specific oncoprotein that is incorporated into the switch/sucrose… read more here.
Keywords: pharmacologic degradation; ss18 ssx; wdr5; synovial sarcoma ... See more keywords
Abstract 2975: Synthetic lethality in synovial sarcoma: SS18-SSX fusions and DNA damage response (DDR) inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2975
Abstract: Aim: Synovial sarcoma (SS) is an aggressive soft-tissue malignancy predominantly affecting the young and characterised by pathognomonic SS18-SSX fusions. Treatment options are limited and therapeutic targeting of SS18-SSX oncoproteins has not yet been achieved. We… read more here.
Keywords: response; sensitivity; ss18 ssx; ss18 ... See more keywords
Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sarcomas17-pr11
Abstract: Synovial sarcoma (SS) is a soft-tissue malignancy driven by a recurrent chromosomal translocation (t(X;18)) that uniformly produces the SS18-SSX oncogenic fusion protein. SS18 is a core subunit of the mammalian SWI/SNF (BAF) complexes, which remodel… read more here.
Keywords: baf47; baf complexes; synovial sarcoma; ss18 ssx ... See more keywords
Paracrine osteoprotegerin and &bgr;-catenin stabilization support synovial sarcomagenesis in periosteal cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci94955
Abstract: Synovial sarcoma (SS) is an aggressive soft-tissue sarcoma that is often discovered during adolescence and young adulthood. Despite the name, synovial sarcoma does not typically arise from a synoviocyte but instead arises in close proximity… read more here.
Keywords: bgr catenin; synovial sarcomagenesis; periosteal cells; ss18 ssx ... See more keywords
SS18-SSX Expression in a Contemporary Cohort of Primary Renal Synovial Sarcoma: A Multi-Institutional Experience of Fourteen Patients.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgical pathology"
DOI: 10.1177/10668969221143481
Abstract: Primary renal synovial sarcoma is a rare aggressive mesenchymal neoplasm of the kidney that accounts for less than 1% of renal sarcomas. Herein, we describe the clinicopathologic and molecular findings of 14 renal synovial sarcoma… read more here.
Keywords: synovial sarcoma; ss18 ssx; renal synovial;
Usefulness of SS18-SSX antibody as a diagnostic marker for pulmonary metastatic synovial sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostic Pathology"
DOI: 10.1186/s13000-021-01110-6
Abstract: Background The novel SS18-SSX fusion-specific antibody is reported to have high sensitivity and specificity for the diagnosis of primary synovial sarcoma (SS), which often metastasizes to the lung. Thus far, no study has validated the… read more here.
Keywords: pulmonary metastatic; antibody; ss18 ssx; ssx ... See more keywords
Therapeutic Potential of Bromodomain and Extra-Terminal Domain Inhibitors for Synovial Sarcoma Cells
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DOI: 10.3390/cancers16061125
Abstract: Simple Summary Synovial sarcoma, a rare type of soft-tissue sarcoma, currently lacks efficacious anticancer therapies. This sarcoma is characterized by the SS18-SSX fusion gene, which plays a pivotal role in epigenetic regulation. Our study centered… read more here.
Keywords: bromodomain extra; ss18 ssx; synovial sarcoma; sarcoma ... See more keywords