Probing the Conformation of an IgG1 Monoclonal Antibody in Lyophilized Solids Using Solid-State Hydrogen-Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).
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DOI: 10.1021/acs.molpharmaceut.7b00696
Abstract: Therapeutic proteins are often formulated as lyophilized products to improve their stability and prolong shelf life. The stability of proteins in the solid-state has been correlated with preservation of native higher order structure and/or molecular… read more here.
Keywords: solid state; state hydrogen; analysis; sshdx ... See more keywords