Blockade of mTOR stimulates hyperglycemia but inhibits severe proteinuria in obese SS rats prior to puberty
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733629
Abstract: Prepubertal obesity (PPO) is a public health problem that is now associated with renal injury. Recently, we reported that the obese SSLepRmutant rat develops inflammation and renal injury before puberty. Moreover, the progression of renal… read more here.
Keywords: physiology; treatment rapamycin; mtor; ssleprmutant rats ... See more keywords
The SGLT2 inhibitor, empagliflozin reduces early progressive proteinuria in obese SS rats
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733738
Abstract: Childhood/prepubertal obesity (PPO) is a world-wide epidemic and is considered a risk factor for renal injury. Therefore, there is a need to control this trend to decrease the future risk of chronic kidney disease. Recently,… read more here.
Keywords: empagliflozin; day; rats day; physiology ... See more keywords
Treatment With Lisinopril Prevents the Early Progression of Glomerular Injury in Obese Dahl Salt-Sensitive Rats Independent of Lowering Arterial Pressure
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.765305
Abstract: Recently, we reported that obese Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats develop glomerular injury and progressive proteinuria prior to puberty. Moreover, this early progression of proteinuria was associated with elevations in GFR. Therefore, the… read more here.
Keywords: glomerular injury; treatment; ssleprmutant rats; treatment lisinopril ... See more keywords