A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31205
Abstract: The pharmacological therapy of GH‐secreting pituitary tumors is based on somatostatin (SS) analogs that reduce GH secretion and cell proliferation by binding mainly SS receptors type 2 (SST2). Antimigratory effects of SS have been demonstrated… read more here.
Keywords: invasion; migration; sst2; cofilin ... See more keywords
The utility of growth differentiation factor-15, galectin-3, and sST2 as biomarkers for the diagnosis of heart failure with preserved ejection fraction and compared to heart failure with reduced ejection fraction: a systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Heart Failure Reviews"
DOI: 10.1007/s10741-020-09913-3
Abstract: The objective was to evaluate the diagnosis of heart failure with preserved ejection fraction (HFpEF) using the biomarkers, growth differentiation factor-15 (GDF-15), galectin-3 (Gal-3), and soluble ST2 (sST2), and to determine whether they can differentiate… read more here.
Keywords: ejection fraction; heart; sst2; heart failure ... See more keywords
The Interleukin-1 Axis and Risk of Death in Patients With Acutely Decompensated Heart Failure.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.11.054
Abstract: BACKGROUND Soluble ST2 (sST2), which is the soluble form of interleukin (IL)-1 receptor-like 1, identifies risk in acutely decompensated heart failure (ADHF). IL-1β is an inflammatory cytokine that has deleterious effects in myocardial remodeling and… read more here.
Keywords: decompensated heart; heart failure; acutely decompensated; sst2 ... See more keywords
Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218033120
Abstract: As a decoy receptor, soluble ST2 (sST2) interferes with the function of the inflammatory cytokine interleukin (IL)-33. Decreased sST2 expression in colorectal cancer (CRC) cells promotes tumor growth via IL-33-mediated bioprocesses in the tumor microenvironment.… read more here.
Keywords: expression; colorectal cancer; sst2; tumor ... See more keywords
sST2 adds to the prognostic value of Gal-3 and BNP in chronic heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Acta Cardiologica"
DOI: 10.1080/00015385.2019.1669847
Abstract: Abstract Background: The soluble form of the IL-33 receptor (sST2) and Galectin-3 (Gal-3) are fibrosis biomarkers with prognostic value in heart failure (HF). We investigated the prognostic capacity of sST2 when combined with Gal-3, and… read more here.
Keywords: prognostic value; gal bnp; heart failure; sst2 gal ... See more keywords
Persistently elevated levels of sST2 after acute coronary syndrome are associated with recurrent cardiac events
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2032350
Abstract: Abstract Purpose Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time in post-ACS patients prior to a recurrent… read more here.
Keywords: coronary syndrome; acute coronary; acs; sst2 ... See more keywords
Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz240
Abstract: Abstract Aims Circulating high-sensitivity cardiac troponin (hsTn) and soluble ST2 (sST2) reflect myocardial stress in patients with heart failure (HF). Production of cyclic guanosine 3′5′ monophosphate (cGMP) in response to activation of natriuretic peptide receptors… read more here.
Keywords: heart; valsartan; sacubitril valsartan; valsartan enalapril ... See more keywords
Serum heart-type fatty acid-binding protein decreases and soluble isoform of suppression of tumorigenicity 2 increases significantly by long-term physical activity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2018-000913
Abstract: The aim of this prospective study was to investigate the influence of long-term physical activity on biomarkers for myocyte ischemia (heart-type fatty acid-binding protein, H-FABP), matrix remodelling/vascular stress (soluble isoform of suppression of tumorigenicity 2,… read more here.
Keywords: fabp; long term; sst2; type ... See more keywords
Predictive Values of Serum IL-33 and sST2 in Endotypes and Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/9155080
Abstract: Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease with high heterogeneity and postoperative recidivation. The IL-33/ST2 axis is known to be involved in Th2 immune responses. This study is aimed at… read more here.
Keywords: sst2; postoperative recurrence; serum sst2; crswnp patients ... See more keywords
Relationship between Soluble ST2 and Left Ventricular Geometry in Maintenance Hemodialysis Patients
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DOI: 10.1159/000508402
Abstract: Introduction: Left ventricular hypertrophy (LVH) is a highly prevalent presentation of cardiac structural abnormality and a strong predictor of adverse outcomes in maintenance hemodialysis (MHD) patients. Different left ventricular geometry may provide additional clinical information.… read more here.
Keywords: ventricular geometry; geometry; sst2; maintenance hemodialysis ... See more keywords
Letter by Zhang and Xu Regarding Article, "Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection".
Sign Up to like & getrecommendations! Published in 2018 at "Circulation"
DOI: 10.1161/circulationaha.118.034582
Abstract: Circulation. 2018;138:1280. DOI: 10.1161/CIRCULATIONAHA.118.034582 1280 https://www.ahajournals.org/journal/circ Li Zhang, MD Xiao-mao Xu, MD To the Editor: We read with great interest the article presented by Yuan Wang and colleagues1 about soluble ST2 (sST2) as a novel… read more here.
Keywords: article; acute aortic; aortic dissection; dissection ... See more keywords