When used together SS18–SSX fusion‐specific and SSX C‐terminus immunohistochemistry are highly specific and sensitive for the diagnosis of synovial sarcoma and can replace FISH or molecular testing in most cases
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DOI: 10.1111/his.14190
Abstract: Synovial sarcoma is defined by recurrent t(X;18)(p11;q11) translocations creating SS18–SSX1, SS18–SSX2 or SS18–SSX4 fusions. Recently, a novel rabbit monoclonal antibody designed to identify these fusions (SS18–SSX, clone E9X9V) was proposed to be highly specific (100%),… read more here.
Keywords: sensitive diagnosis; synovial sarcoma; highly specific; ss18 ssx ... See more keywords
Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma
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DOI: 10.1158/1557-3265.sarcomas17-pr11
Abstract: Synovial sarcoma (SS) is a soft-tissue malignancy driven by a recurrent chromosomal translocation (t(X;18)) that uniformly produces the SS18-SSX oncogenic fusion protein. SS18 is a core subunit of the mammalian SWI/SNF (BAF) complexes, which remodel… read more here.
Keywords: baf47; baf complexes; synovial sarcoma; ss18 ssx ... See more keywords
Usefulness of SS18-SSX antibody as a diagnostic marker for pulmonary metastatic synovial sarcoma
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DOI: 10.1186/s13000-021-01110-6
Abstract: Background The novel SS18-SSX fusion-specific antibody is reported to have high sensitivity and specificity for the diagnosis of primary synovial sarcoma (SS), which often metastasizes to the lung. Thus far, no study has validated the… read more here.
Keywords: pulmonary metastatic; antibody; ss18 ssx; ssx ... See more keywords