The potential role and regulatory mechanism of IL-33/ST2 axis on T lymphocytes during lipopolysaccharide stimulation or perinatal Listeria infection.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108742
Abstract: BACKGROUND Interleukin-33 (IL-33) is a member of the interleukin-1 family, which is reported to be important across a range of diseases. However, the mechanisms underlying IL-33/ST2 axis in infectious diseases have not yet been fully… read more here.
Keywords: st2 axis; st2; infection; mechanism ... See more keywords
Potential role of the IL-33/ST2 axis in celiac disease
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2015.85
Abstract: The IL-33/ST2 axis has been implicated in the pathogenesis of several tissue-specific autoimmune diseases. Celiac disease (CD) is the only autoimmune disease in which both the major genetic factors (HLA-DQ2/DQ8) and etiologic ones (dietary gluten)… read more here.
Keywords: st2 axis; disease; tissue; celiac disease ... See more keywords
P12.58.A ROLE OF IL-33/ST2 AXIS IN GLIOBLASTOMA DEVELOPMENT AND ITS RESPONSE TO TREATMENT
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf193.437
Abstract: Glioblastoma (GBM) is the most aggressive and lethal primary brain tumour, characterised by rapid proliferation, extensive migration, and resistance to therapies driven by stem-like GBM cells. Inflammatory pathways may play a critical role in modulating… read more here.
Keywords: role; migration; gbm; cell ... See more keywords
The IL-33/ST2 axis promotes ARDS by killing natural T cells.
Sign Up to like & getrecommendations! Published in 2023 at "Shock"
DOI: 10.1097/shk.0000000000002114
Abstract: ABSTRACT Acute respiratory distress syndrome (ARDS) is characterized by uncontrolled inflammation, which manifests as leukocyte infiltration and lung injury. However, the molecules that initiate this infiltration remain incompletely understood. We evaluated the effect of the… read more here.
Keywords: lung injury; lung; mice; axis promotes ... See more keywords
IL-33/ST2 axis mediates diesel exhaust particles-induced mast cell activation
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-01035-y
Abstract: Mast cells are implicated in the pathogenesis and severity of asthma in children and adults. The release of proinflammatory mediators and cytokines from activated mast cells (MC) is associated with Type 2 (T2) cell-skewed inflammation.… read more here.
Keywords: diesel exhaust; cell; mast; expression ... See more keywords
Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0700-2
Abstract: BackgroundEmerging evidence has suggested that interleukin (IL)-33 and its primary functional receptor ST2 are involved in the pathogenesis of tumorigenesis.MethodsUsing immunohistochemistry (IHC) and double immunofluorescence staining, we characterized the cellular and clinicopathological features of the… read more here.
Keywords: cellular clinicopathological; st2 axis; features st2; human esophageal ... See more keywords
IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s336404
Abstract: Purpose Schistosoma japonicum-infected IL-33 and ST2 gene deficiency (IL-33−/− and ST2−/−, respectively) mice were used to explore the role of the IL-33/ST2 axis in liver pathology targeting regulatory T cells (Treg)/T helper 17 cells (Th17).… read more here.
Keywords: st2 axis; infected mice; st2; pathology ... See more keywords
Deficiency in IL-33/ST2 Axis Reshapes Mitochondrial Metabolism in Lipopolysaccharide-Stimulated Macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00127
Abstract: The polarization and function of macrophages play essential roles in controlling immune responses. Interleukin (IL)-33 is a member of the IL-1 family that has been shown to influence macrophage activation and polarization, but the underlying… read more here.
Keywords: metabolism; st2 axis; polarization; mitochondrial metabolism ... See more keywords
The IL-33/ST2 Axis Promotes Traumatic Heterotopic Ossification by Driving Macrophage and Mast Cell-Mediated Inflammation via Autophagy Defects
Sign Up to like & getrecommendations! Published in 2026 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.122706
Abstract: Trauma-induced Heterotopic ossification (tHO) is the abnormal osteogenesis occurring in soft tissues after traumatic musculoskeletal injury, which can lead to severe limb movement impairment or even disability. Recent studies have indicated that macrophages and mast… read more here.
Keywords: macrophage mast; mast cells; mast; autophagy ... See more keywords