Spinal IL‐33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2‐STAT3 cascade
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DOI: 10.1002/glia.23639
Abstract: Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation and chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of chronic itch induced by poison ivy.… read more here.
Keywords: itch; spinal st2; chronic itch; st2 signaling ... See more keywords
The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01429-2
Abstract: Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated neuroinflammation. WIN 55,212-2, a non-selective agonist of cannabinoid receptors, has been demonstrated to have anti-inflammatory properties… read more here.
Keywords: microglial polarization; microglia; win 212; st2 signaling ... See more keywords
The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy
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DOI: 10.1177/15353702221102094
Abstract: Interleukin (IL)-33 is a tissue-derived nuclear cytokine belonging to the IL-1 family. Stimulation-2 (ST2) is the only known IL-33 receptor. ST2 signals mostly on immune cells found within tissues, such as regulatory T cells (Treg… read more here.
Keywords: st2 signaling; role st2; treg immunotherapy; tumor microenvironment ... See more keywords
Corrigendum: Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression
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DOI: 10.3389/fimmu.2020.592865
Abstract: [This corrects the article DOI: 10.3389/fimmu.2019.00702.]. read more here.
Keywords: signaling attenuates; corrigendum blockade; 33r st2; st2 signaling ... See more keywords