Transient downregulation of NR4A1 leads to impaired osteoblast differentiation through the TGF-ß pathway, and Elesclomol (STA-4783) rescues this phenotype.
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DOI: 10.1002/cbf.3814
Abstract: Bone formation is regulated by numerous factors, such as transcription factors, cytokines, and extracellular matrix molecules. Human hormone nuclear receptors (hHNR) are a family of ligand-regulated transcription factors that are activated by steroid hormones, such… read more here.
Keywords: tgf pathway; elesclomol sta; sta 4783; differentiation ... See more keywords