One-pot thiol–amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisationâ€
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DOI: 10.1039/d0sc05128d
Abstract: Maleimide chemistry is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous… read more here.
Keywords: dual functionalisation; thiol amine; stabilisation dual; one pot ... See more keywords