Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox.
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DOI: 10.1021/acs.jmedchem.7b01444
Abstract: Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas. Some hydroxamic acids display a high plasma clearance resulting in poor in vivo… read more here.
Keywords: toolbox; plasma stability; chemistry; hydroxamic acids ... See more keywords