Stability Indicating RP-HPLC method for Methylcobalamin determination in different dosage forms: application to photodegradation kinetics and pH-rate profiling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200132
Abstract: A stability-indicating RP-HPLC method for methylcobalamin determination was developed. Stress degradation under variable conditions was carried out. Methylcobalamin had pronounced susceptibility to hydrolysis under acidic, alkaline, and photolytic conditions; further study of photolytic degradation kinetics… read more here.
Keywords: stability indicating; rate; determination; method ... See more keywords
Development and validation of a novel stability-indicating reverse phase HPLC method for the determination of sacubitril-valsartan premix stereoisomers: Cellulose tris(4-methyl benzoate) stationary phase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200363
Abstract: A new stability indicating reverse phase HPLC method has been developed, optimized and validated as per International Conference on Harmonization guidelines for the determination of stereoisomers namely (2R)-valsartan, (2S,4S)-sacubitril, (2R,4S)-sacubitril and (2R,4R)-sacubitril in sacubitril-valsartan premix.… read more here.
Keywords: sacubitril valsartan; stability indicating; reverse phase; sacubitril ... See more keywords
Development, stability-Indicating assessment, and evaluation of influential method conditions using a full factorial design for the determination of Nintedanib Esylate related impurities.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202200770
Abstract: The design of an appropriate analytical method for assessing the quality of pharmaceuticals requires a deep understanding of science, and risk evaluation approaches are appreciated. The current study discusses how a related substance method was… read more here.
Keywords: stability indicating; method conditions; nintedanib esylate; design ... See more keywords
A Highly Selective Stability-Indicating HPLC Method for Simultaneous Estimation of Sertaconazole with Two Coformulated Preservatives in Pharmaceutical Dosage Forms
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DOI: 10.1007/s10337-019-03832-8
Abstract: Abstract The present investigation deals with the development of a validated stability-indicating HPLC–DAD method for the simultaneous determination of sertaconazole nitrate (SN) and two coformulated preservatives: sorbic acid (SA) and methylparaben (MP). The analytes were subjected to… read more here.
Keywords: stability indicating; method; indicating hplc; method simultaneous ... See more keywords
Two-wavelength manipulation stability-indicating spectrophotometric methods for determination of meropenem and ertapenem: greenness consolidation and pharmaceutical product application
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DOI: 10.1007/s11696-019-00824-8
Abstract: Green assessed, UV-spectrophotometric methods were developed and validated for estimation of meropenem (MP) and ertapenem (EP), categorized to be non-classical β-lactam antibiotics, in the presence of their corresponding oxidative and hydrolytic degradants. The methods were… read more here.
Keywords: determination; spectrophotometric methods; stability indicating; meropenem ertapenem ... See more keywords
Stability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS
Sign Up to like & getrecommendations! Published in 2019 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2014.11.044
Abstract: Abstract In this stability-indicating, reversed-phase high-performance liquid chromatographic method for nicardipine (NIC), forced degradation has been employed and the formed degradants were separated on a C18 (150 mm × 3.9 mm, 5 μm) analytical column using a mobile phase consisted… read more here.
Keywords: degradation products; method; stability indicating; spiked human ... See more keywords
A comprehensive approach for the simultaneous analysis of all main water-soluble vitamins in multivitamin preparations by a stability-indicating HPLC-DAD method.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.127768
Abstract: A stability-indicating HPLC-DAD method for simultaneous determination of all nine main water-soluble vitamins, in addition to two commonly used vitamers, was developed and fully validated in analytical ranges, adjusted to their recommended dietary allowance values.… read more here.
Keywords: soluble vitamins; analysis; stability indicating; water soluble ... See more keywords
A stability-indicating HPLC-UV method for the quantification of anthocyanin in Roselle (Hibiscus Sabdariffa L.) spray-dried extract, oral powder, and lozenges
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DOI: 10.1016/j.heliyon.2022.e09177
Abstract: Hibiscus sabdariffa L. (H.S.) plant and its calyces have received much attention from researchers because of their potential medicinal and nutritional values. Calyces are the major source of anthocyanin in this plant. Therefore, a well-developed,… read more here.
Keywords: method; stability indicating; hibiscus sabdariffa; hplc method ... See more keywords
Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2016.09.037
Abstract: A stability indicating high performance liquid chromatography method has been developed for the determination of thiocolchicoside (TCC) and its main degradation products thiocolchicoside S-oxide (D1SO) and 3-O-demethylthiocolchicine (D3) in liquid and solid formulations. The method… read more here.
Keywords: degradation; determination thiocolchicoside; stability indicating; method ... See more keywords
A four parameter optimization and troubleshooting of a RPLC – charged aerosol detection stability indicating method for determination of S‐lysophosphatidylcholines in a phospholipid formulation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.03.067
Abstract: HIGHLIGHTSCharged aerosol detection of S‐lysophosphatidylcholines in phospholipid formulation.HPLC columns were chosen based on the hydrophobic subtraction model for screening.HPLC conditions were selected to give a stability indicating separation.Optimal power function values were different between two… read more here.
Keywords: lysophosphatidylcholines phospholipid; stability indicating; optimization; aerosol detection ... See more keywords
A stability-indicating LC-MS/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113150
Abstract: A stability-indicating high-performance liquid chromatography method for Pemetrexed bulk was developed and validated as per the ICH guidelines by employing design of experiments methodology equipped with Box-Behnken design. The separation of Pemetrexed and its oxidative… read more here.
Keywords: degradation; degradation product; stability indicating; oxidative degradation ... See more keywords