Application of MetMax™ pooled donor human hepatocytes in a higher throughput assay for human hepatic metabolic stability screening
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Pharmacokinetics"
DOI: 10.1016/j.dmpk.2017.11.208
Abstract: • Both MetMaxTM and Intact Human Hepatocytes yielded data comparable to clinical systemic clearance One interesting finding was that MetMaxTM hepatocytes were superior to pooled cryopreserved human hepatocytes in the evaluation of afatinib, a drug… read more here.
Keywords: stability screening; metabolic stability; pooled donor; drug ... See more keywords
Nano Differential Scanning Fluorimetry-Based Thermal Stability Screening and Optimal Buffer Selection for Immunoglobulin G
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph15010029
Abstract: Nano differential scanning fluorimetry (nanoDSF) is a high-throughput protein stability screening technique that simultaneously monitors protein unfolding and aggregation properties. The thermal stability of immunoglobulin G (IgG) was investigated in three different buffers (sodium acetate,… read more here.
Keywords: acetate; nano differential; stability screening; thermal stability ... See more keywords