Dynamic-mechanical thermoanalysis test as a high-performance alternative for accelerated freeze-thaw stability testing: a case study of O/W emulsions
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1730399
Abstract: Abstract Objective: The main objective of this work was to evaluate the performance of recently developed dynamic-mechanical thermoanalysis (DMTA) test as a rapid rheological alternative to conventional freeze-thaw cycling for accelerated stability testing of oil-in-water… read more here.
Keywords: dynamic mechanical; freeze thaw; test; stability ... See more keywords
Automated Stability Testing of Elastic Rods With Helical Centerlines Using a Robotic System
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Robotics and Automation Letters"
DOI: 10.1109/lra.2021.3138532
Abstract: Experimental analysis of the mechanics of a deformable object, and particularly its stability, requires repetitive testing and, depending on the complexity of the object’s shape, a testing setup that can manipulate many degrees of freedom… read more here.
Keywords: automated stability; system; using robotic; robotic system ... See more keywords
Quantification of Grapiprant and Its Stability Testing under Changing Environmental Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112821
Abstract: Grapiprant is a new analgesic and anti-inflammatory drug belonging to the piprant class, approved in 2016 by the FDA Veterinary Medicine Center for the treatment of pain and inflammation associated with osteoarthritis in dogs. It… read more here.
Keywords: environmental conditions; grapiprant stability; testing changing; quantification grapiprant ... See more keywords
Replicates Number for Drug Stability Testing during Bioanalytical Method Validation—An Experimental and Retrospective Approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27020457
Abstract: Background: The stability of a drug or metabolites in biological matrices is an essential part of bioanalytical method validation, but the justification of its sample size (replicates number) is insufficient. The international guidelines differ in… read more here.
Keywords: method validation; confidence intervals; bioanalytical method; stability ... See more keywords