Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00985
Abstract: Peptide modulators targeting protein-protein interactions (PPIs) exhibit greater potential than small-molecule drugs in several important aspects including facile modification and relative large contact surface area. Stabilized peptides constructed by variable chemistry methods exhibit improved peptide… read more here.
Keywords: peptide; stabilized peptide; peptide based; protacs ... See more keywords
Assigning biological function using hidden signatures in cystine-stabilized peptide sequences
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27177-8
Abstract: Cystine-stabilized peptides have great utility as they naturally block ion channels, inhibit acetylcholine receptors, or inactivate microbes. However, only a tiny fraction of these peptides has been characterized. Exploration for novel peptides most efficiently starts… read more here.
Keywords: peptide sequences; cystine stabilized; stabilized peptide; hidden signatures ... See more keywords