Nanosuspensions of a poorly soluble investigational molecule ODM-106: impact of milling bead diameter and stabilizer concentration.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119636
Abstract: Aqueous solubility of a drug substance is an important attribute affecting oral bioavailability. Nanonization, particle size reduction to submicron level, is an elegant approach to improve drug solubility and dissolution by increasing the surface energy,… read more here.
Keywords: bead diameter; investigational molecule; diameter stabilizer; milling bead ... See more keywords
Effects of Lateral Size, Thickness, and Stabilizer Concentration on the Cytotoxicity of Defect-Free Graphene Nanosheets: Implications for Biological Applications
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Nano Materials"
DOI: 10.1021/acsanm.2c02403
Abstract: In this work, we apply liquid cascade centrifugation to highly concentrated graphene dispersions produced by liquid-phase exfoliation in water with an insoluble bis-pyrene stabilizer to obtain fractions containing nanosheets with different lateral size distributions. The… read more here.
Keywords: size thickness; lateral size; stabilizer; stabilizer concentration ... See more keywords