Dual Functionality of Poloxamer 188 in Freeze-Dried Protein Formulations: A Stabilizer in Frozen Solutions and a Bulking Agent in Lyophiles.
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DOI: 10.1021/acs.molpharmaceut.4c00108
Abstract: Poloxamer 188 (P188) was hypothesized to be a dual functional excipient, (i) a stabilizer in frozen solution to prevent ice-surface-induced protein destabilization and (ii) a bulking agent to provide elegant lyophiles. Based on X-ray diffractometry… read more here.
Keywords: stabilizer frozen; bulking agent; freeze; dried protein ... See more keywords