Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.268
Abstract: The oncogenic transcription factor c-MYC (MYC) is deregulated and often overexpressed in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease, suggesting that the development of therapeutic inhibitors targeting… read more here.
Keywords: stabilizes myc; mechanism; scffbxw7 independent; myc oncoprotein ... See more keywords
Abstract 5423: Lysine-52 stabilizes the MYC oncoprotein through a SCFFBXW7-independent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5423
Abstract: The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease, suggesting that the development of therapeutic inhibitors targeting… read more here.
Keywords: stabilizes myc; mechanism; scffbxw7 independent; myc oncoprotein ... See more keywords
SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851089
Abstract: UDP-GlcNAc is a sugar substrate necessary for the O-GlcNAcylation of proteins. SLC35B4 is one of the nucleotide sugar transporters that transport UDP-GlcNAc and UDP-xylose into the endoplasmic reticulum and Golgi apparatus for glycosylation. The roles… read more here.
Keywords: myc protein; glcnacylation; hcc; slc35b4 stabilizes ... See more keywords