Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models
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DOI: 10.1021/acscentsci.7b00465
Abstract: Protein stabilization is fundamental to enzyme function and evolution, yet understanding the determinants of a protein’s stability remains a challenge. This is largely due to a shortage of atomically detailed models for the ensemble of… read more here.
Keywords: prediction new; new stabilizing; stabilizing mutations; markov state ... See more keywords
Evolution avoids a pathological stabilizing interaction in the immune protein S100A9
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208029119
Abstract: Stability constrains evolution. While much is known about constraints on destabilizing mutations, less is known about the constraints on stabilizing mutations. We recently identified a mutation in the innate immune protein S100A9 that provides insight… read more here.
Keywords: interaction; stabilizing mutations; protein s100a9; protein ... See more keywords
Kinetically Stabilizing Mutations in Beta Tubulins Create Isotype-Specific Brain Malformations
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.765992
Abstract: Mutations in the family of genes encoding the tubulin subunits of microtubules are associated with a spectrum of human brain malformations known as tubulinopathies. How these mutations impact tubulin activity to give rise to distinct… read more here.
Keywords: brain malformations; tubulin; kinetically stabilizing; brain ... See more keywords