Polypeptide and glycosaminoglycan polysaccharide as stabilizing polymers in nanocrystals for a safe ocular hypotensive effect.
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DOI: 10.1016/j.ijbiomac.2020.07.306
Abstract: Improved ocular delivery of a poorly soluble anti-glaucoma drug, acetazolamide (ACZ), in a stable nanosuspension (NS) was the main target of the study. The anionic polypeptide, poly-γ-glutamic acid (PG) and the glycosaminoglycan, hyaluronic acid, were… read more here.
Keywords: glycosaminoglycan polysaccharide; polymers nanocrystals; ocular hypotensive; polypeptide glycosaminoglycan ... See more keywords