Stable Amide Activation of N-Acetylated Glycosamines for the Synthesis of Fused Polycyclic Glycomimetics.
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DOI: 10.1021/acs.orglett.3c03803
Abstract: N-Acetylation of carbohydrates is an underexplored target for chemoselective derivatization and generation of glycomimetic scaffolds. Through mild amide activation, we report that N-acetimidoyl heterocycles are stable in neutral or basic conditions yet are excellent leaving… read more here.
Keywords: amide activation; glycosamines synthesis; stable amide; activation ... See more keywords