A stable association with PME‐1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation
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DOI: 10.1002/2211-5463.12485
Abstract: Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer and neurodegenerative disorders. Protein… read more here.
Keywords: stable association; methylation; association pme; demethylation ... See more keywords
Mammalian nuclear speckles exhibit stable association with chromatin: a biochemical study
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DOI: 10.1080/19491034.2021.2024948
Abstract: ABSTRACT Nuclear Speckles (NS) are phase-separated condensates of protein and RNA whose components dynamically coordinate RNA transcription, splicing, transport and DNA repair. NS, probed largely by imaging studies, remained historically well known as Interchromatin Granule… read more here.
Keywords: association chromatin; nuclear speckles; exhibit stable; chromatin ... See more keywords