Bioinspired peptide stapling generates stable enzyme inhibitors.
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DOI: 10.1039/d2cc03510c
Abstract: Stapling of peptides renders them better drug candidates. We report a new peptide staple resembling the natural metabolite lanthionine ketenamine. The strategy is orthogonal to canonical amino acids, proceeds in water and allows for tailored… read more here.
Keywords: stable enzyme; stapling generates; enzyme inhibitors; peptide stapling ... See more keywords