Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application.
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DOI: 10.1021/acs.analchem.7b01830
Abstract: The following work describes a combined enzymatic and bioanalytical method that permits absolute quantitation of metabolites in biological samples without the requirement for reference metabolite standards. This technique was exemplified using a radio (14C) isotopologue… read more here.
Keywords: stable isotopologues; absolute quantitation; radio; radio stable ... See more keywords