A CHO stable pool production platform for rapid clinical development of trimeric SARS-CoV-2 spike subunit vaccine antigens.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28387
Abstract: Protein expression from stably transfected Chinese hamster ovary (CHO) clones is an established but time-consuming method for manufacturing therapeutic recombinant proteins. The use of faster, alternative approaches, such as non-clonal stable pools, has been restricted… read more here.
Keywords: cov spike; trimeric sars; cho; production ... See more keywords
Towards Maximum Acceleration of Monoclonal Antibody Development: Leveraging Transposase-Mediated Cell Line Generation to Enable GMP Manufacturing within 3 Months using a Stable Pool.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2022.03.010
Abstract: In recent years, acceleration of development timelines has become a major focus within the biopharmaceutical industry to bring innovative therapies faster to patients. However, in order to address a high unmet medical need even faster… read more here.
Keywords: development; cell line; stable pool; gmp ... See more keywords