Abstract 3452: The cohesin subunitSTAG1is a hardwired genetic dependency ofSTAG2mutant cancer cells
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DOI: 10.1158/1538-7445.am2017-3452
Abstract: Recent genome analyses have identified recurrent mutations in subunits of the cohesin complex in human cancer. Cohesin is a chromosomal factor that is essential for sister chromatid cohesion and cell division and that contributes to… read more here.
Keywords: stag2; genetic dependency; cohesin; cancer ... See more keywords
Abstract 4399: Exploring the postmitotic roles of STAG2 mutations in solid tumors
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DOI: 10.1158/1538-7445.sabcs18-4399
Abstract: Mutations in the cohesin complex are associated with cancer, in particular Ewing’s Sarcoma (EWS) and bladder cancer. The STAG2 subunit of cohesin is essential for its loading onto chromatin and proper function of the complex.… read more here.
Keywords: stag2; ews cells; cancer; ewsr1 fli1 ... See more keywords
Loss of Stromal Antigen 2 (STAG2) Expression in Upper Urinary Tract Carcinoma: Differential Prognostic Effect According to the Ki-67 Proliferating Index
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DOI: 10.1245/s10434-017-6097-7
Abstract: BackgroundInactivating mutation and consequent expression loss of stromal antigen 2 (STAG2, also known as SA2), a component of the cohesion complex, is one of the most common genetic aberrations in urothelial carcinoma. However, the clinicopathologic… read more here.
Keywords: carcinoma; stag2; loss stromal; stromal antigen ... See more keywords