Regioselective C–H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds
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DOI: 10.1039/c7ra09939h
Abstract: We have developed a protocol for the auxillary directed C–H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone. The 2-pyridine group allows… read more here.
Keywords: phenol derivatives; late stage; chlorination; stage chlorination ... See more keywords