LAUSR

Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents

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0 Published in 2024 at "ChemMedChem"

DOI: 10.1002/cmdc.202400028

Abstract: N‐Pyrazolylcarboxamides and N‐pyrazolylureas represent promising lead compounds for the development of novel antileishmanial drugs. Herein, we report the late‐stage diversification of 3‐bromopyrazoles 10 A/B and 14 A by Pd‐catalyzed Sonogashira and Suzuki‐Miyaura cross coupling reactions. The electron‐withdrawing… read more here.

Keywords: position; late stage; moiety; stage diversification ... See more keywords

Late-Stage Diversification of Phosphines by C-H Activation: A Robust Strategy for Ligand Design and Preparation.

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0 Published in 2024 at "Accounts of chemical research"

DOI: 10.1021/acs.accounts.4c00020

Abstract: ConspectusThe advent of the twenty-first century marked a golden era in the realm of synthetic chemistry, exemplified by groundbreaking advancements in the field of C-H activation, which is a concept that quickly transitioned from mere… read more here.

Keywords: chemistry; stage diversification; late stage; activation ... See more keywords

Late-Stage Diversification of Biarylphosphines through Rhodium(I)-Catalyzed C-H Bond Alkenylation with Internal Alkynes.

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0 Published in 2020 at "Organic letters"

DOI: 10.1021/acs.orglett.0c02023

Abstract: We report herein P(III)-directed C-H bond alkenylation of (dialkyl)- and (diaryl)biarylphosphines using internal alkynes. Chloride-free [Rh(OAc)(COD)]2 acts as a better catalyst than commercially available [RhCl(COD)]2. Conditions were developed to control the mono- and difunctionalization depending… read more here.

Keywords: internal alkynes; bond alkenylation; late stage; stage diversification ... See more keywords

Ad Hoc Adjustment of Photoredox Properties by the Late-Stage Diversification of Acridinium Photocatalysts.

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0 Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c01673

Abstract: The steadily growing interest in substituting precious-metal photoredox catalysts with organic surrogates is vibrantly sustained by emerging methodologies to vary their photochemical behavior. Herein, we report an ad hoc approach for the preparation of acridinium… read more here.

Keywords: acridinium; late stage; stage diversification; acridinium photocatalysts ... See more keywords

Late-stage diversification of bacterial natural products through biocatalysis

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0 Published in 2024 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2024.1351583

Abstract: Bacterial natural products (BNPs) are very important sources of leads for drug development and chemical novelty. The possibility to perform late-stage diversification of BNPs using biocatalysis is an attractive alternative route other than total chemical… read more here.

Keywords: bacterial natural; late stage; biocatalysis; stage diversification ... See more keywords