Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy: A Pooled Analysis From 2 Randomized Clinical Trials
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DOI: 10.1001/jamaoncol.2017.2899
Abstract: Importance The prognostic impact of DNA mismatch repair (MMR) status in stage III colon cancer patients receiving FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy remains controversial. Objective To determine the association of MMR status… read more here.
Keywords: status; stage iii; iii colon; colon cancer ... See more keywords
Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo: A Secondary Analysis of a Randomized Clinical Trial.
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DOI: 10.1001/jamaoncol.2019.5570
Abstract: Importance Whether immune-related adverse events (irAEs) indicate drug activity in patients treated with immune checkpoint inhibitors remains unknown. Objective To investigate the association between irAEs and recurrence-free survival (RFS) in the double-blind EORTC 1325/KEYNOTE-054 clinical… read more here.
Keywords: melanoma; arm; stage iii; recurrence ... See more keywords
Comparing Trial and Real-world Adjuvant Oxaliplatin Delivery in Patients With Stage III Colon Cancer Using a Longitudinal Cumulative Dose.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.4445
Abstract: Importance Delivery of adjuvant chemotherapy can differ substantially between trial and real-world populations. Adherence metrics like relative dose intensity (RDI) cannot capture the timing of modifications and mask differences in the total amount of chemotherapy… read more here.
Keywords: oncology; trial; stage iii; colon cancer ... See more keywords
Nomogram for predicting overall survival in stage II‐III colorectal cancer
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DOI: 10.1002/cam4.2896
Abstract: The overall survival (OS) of patients diagnosed with stage II‐III colorectal cancer (CRC) can vary greatly, even between patients with the same tumor stage. We aimed to design a nomogram to predict OS in resected,… read more here.
Keywords: stage iii; colorectal cancer; iii colorectal; overall survival ... See more keywords
A novel deep learning prognostic system improves survival predictions for stage III non‐small cell lung cancer
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DOI: 10.1002/cam4.4782
Abstract: Accurate prognostic prediction plays a crucial role in the clinical setting. However, the TNM staging system fails to provide satisfactory individual survival prediction for stage III non‐small cell lung cancer (NSCLC). The performance of the… read more here.
Keywords: non small; iii non; stage iii; small cell ... See more keywords
Real‐world KINDLE‐Latin America subset data on treatment patterns and clinical outcomes in patients with stage III non‐small‐cell lung cancer
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DOI: 10.1002/cam4.4990
Abstract: Stage III non‐small‐cell lung cancer (NSCLC) management is challenging given the heterogeneous nature of the disease. The LATAM subset of the real‐world, global KINDLE study reported the treatment patterns and clinical outcomes for LATAM from… read more here.
Keywords: non small; iii non; stage iii; small cell ... See more keywords
The new ‘coN’ staging system combining lymph node metastasis and tumour deposit provides a more accurate prognosis for TNM stage III colon cancer
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DOI: 10.1002/cam4.5099
Abstract: Despite controversy over its origin and definition, the significance of tumour deposit (TD) has been underestimated in the tumour node metastasis (TNM) staging system for colon cancer, especially in stage III patients. We aimed to… read more here.
Keywords: staging system; node metastasis; stage iii; colon cancer ... See more keywords
Can we eliminate neoadjuvant chemoradiotherapy in favor of neoadjuvant multiagent chemotherapy for select stage II/III rectal adenocarcinomas: Analysis of the National Cancer Data base
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DOI: 10.1002/cncr.30410
Abstract: Stage II and III rectal cancers have been effectively treated with neoadjuvant chemoradiotherapy (NCRT) followed by definitive resection. Advancements in surgical technique and systemic therapy have prompted investigation of neoadjuvant multiagent chemotherapy (NMAC) regimens with… read more here.
Keywords: stage iii; neoadjuvant chemoradiotherapy; neoadjuvant multiagent; cancer ... See more keywords
Some stage III colon cancer patients may need only half of the standard chemotherapy course
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DOI: 10.1002/cncr.31042
Abstract: 3871 Content in this section does not reflect any official policy or medical opinion of the American Cancer Society or of the publisher unless otherwise noted. © American Cancer Society, 2017. • The rate at… read more here.
Keywords: project; stage iii; iii colon; project genie ... See more keywords
Marine omega‐3 fatty acid intake and survival of stage III colon cancer according to tumor molecular markers in NCCTG Phase III trial N0147 (Alliance)
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DOI: 10.1002/ijc.32113
Abstract: Marine omega‐3 polyunsaturated fatty acids (MO3PUFAs) have anticancer properties and may improve colon cancer survival. However, it remains unknown whether the benefit differs by tumor molecular subtype. We examined data from a phase III randomized… read more here.
Keywords: stage iii; tumor molecular; colon cancer; cancer ... See more keywords
RNA sequencing reveals PNN and KCNQ1OT1 as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy
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DOI: 10.1002/ijc.32326
Abstract: Five‐year overall survival of stage III colorectal cancer (CRC) patients treated with standard adjuvant chemotherapy (ACHT) is highly variable. Genomic biomarkers and/or transcriptomic profiles identified lack of adequate validation. Aim of our study was to… read more here.
Keywords: stage iii; pnn kcnq1ot1; crc patients; cancer ... See more keywords