Neoadjuvant external beam radiation is associated with No benefit in overall survival for early stage pancreatic cancer.
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DOI: 10.1016/j.amjsurg.2016.11.039
Abstract: OBJECTIVE Neoadjuvant protocols for early stage pancreatic adenocarcinoma (PDAC) frequently involve external beam radiation used in combination with systemic chemotherapy. The benefit of radiation in these protocols has not been determined. METHODS We examined patients… read more here.
Keywords: benefit; stage pancreatic; early stage; overall survival ... See more keywords
Natural History of Stage IV Pancreatic Cancer. Identifying Survival Benchmarks for Curative-intent Resection in Patients With Synchronous Liver-only Metastases.
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DOI: 10.1097/sla.0000000000005753
Abstract: OBJECTIVE To evaluate long-term oncologic outcomes of patients with stage IV pancreatic ductal adenocarcinoma (PDAC) and identify survival benchmarks for comparison when considering resection in these patients. SUMMARY BACKGROUND DATA Highly selected cohorts of patients… read more here.
Keywords: survival benchmarks; synchronous liver; resection patients; resection ... See more keywords
NAMPT expression in stage I/II pancreatic ductal adenocarcinoma.
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DOI: 10.1200/jco.2017.35.15_suppl.e15735
Abstract: e15735Background: NAD (nicotinamide adenine dinucleotide), a vital cofactor in redox reactions and a substrate for many enzymes, plays a critical role in cellular metabolism. NAMPT (nicotinamide ph... read more here.
Keywords: expression stage; stage pancreatic; pancreatic ductal; ductal adenocarcinoma ... See more keywords
A phase Ib/II pilot trial with nab-paclitaxel plus gemcitabine plus cisplatin in patients (pts) with stage IV pancreatic cancer.
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DOI: 10.1200/jco.2017.35.4_suppl.341
Abstract: 341Background: Genomes of metastatic pancreatic cancers frequently contain intrachromosomal aberrations indicating DNA repair abnormalities associated with sensitivity to DNA damaging agents such as the platinums. Cisplatin was added to a nab-paclitaxel + gemcitabine regimen, which… read more here.
Keywords: nab paclitaxel; cisplatin patients; stage pancreatic; plus cisplatin ... See more keywords
Surgical intervention in early-stage pancreatic adenocarcinoma.
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DOI: 10.1200/jco.2017.35.4_suppl.443
Abstract: 443Background: Bilimoria et al (2007) reviewed 9,559 patients from the 1995-2004 National Cancer Database (NCDB) showing that 38.2% of patients with early-stage pancreatic cancer without any identifiable contraindications failed to undergo pancreactomy. We used the… read more here.
Keywords: stage pancreatic; pancreatic adenocarcinoma; early stage; stage ... See more keywords
Impact of hospital teaching status on stage I pancreatic cancer survival.
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DOI: 10.1200/jco.2018.36.4_suppl.257
Abstract: 257Background: Burke et al. (2017) revealed that academic hospitals had lower patient mortality rates for common conditions compared to community-based hospitals. We conducted a retrospective study to compare survival of Stage I pancreatic cancer patients… read more here.
Keywords: stage pancreatic; impact hospital; pancreatic cancer; stage ... See more keywords
National Use of Chemotherapy in Initial Management of Stage I Pancreatic Cancer and Failure to Perform Subsequent Resection
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DOI: 10.1245/s10434-019-08023-1
Abstract: Introduction Chemotherapy is increasingly administered prior to resection in patients with early-stage pancreatic adenocarcinoma, but the national prevalence of this practice is poorly understood. Our objectives were to (1) describe the utilization of upfront chemotherapy… read more here.
Keywords: chemotherapy; upfront chemotherapy; stage pancreatic; subsequent resection ... See more keywords
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease
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DOI: 10.21873/anticanres.15734
Abstract: Background: Pancreatic cancer is one of the most recalcitrant cancers, and more effective therapy is needed. Pre-clinical studies have shown that patient-derived orthotopic xenograft (PDOX) mouse models of pancreatic cancer are effectively treated with oral… read more here.
Keywords: folfirinox; pancreatic cancer; patient; cancer ... See more keywords