The transcriptome of circulating sexually committed Plasmodium falciparum ring stage parasites forecasts malaria transmission potential
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DOI: 10.1038/s41467-020-19988-z
Abstract: Malaria is spread by the transmission of sexual stage parasites, called gametocytes. However, with Plasmodium falciparum, gametocytes can only be detected in peripheral blood when they are mature and transmissible to a mosquito, which complicates… read more here.
Keywords: ring stage; transmission; plasmodium falciparum; stage parasites ... See more keywords
Evaluating antimalarial efficacy by tracking glycolysis in Plasmodium falciparum using NMR spectroscopy
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DOI: 10.1038/s41598-018-36197-3
Abstract: Glucose is an essential nutrient for Plasmodium falciparum and robust glycolytic activity is indicative of viable parasites. Using NMR spectroscopy, we show that P. falciparum infected erythrocytes consume ~20 times more glucose, and trophozoites metabolize… read more here.
Keywords: using nmr; falciparum; nmr spectroscopy; plasmodium falciparum ... See more keywords
Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome
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DOI: 10.1128/spectrum.00147-23
Abstract: The disease African trypanosomiasis imposes a severe human and economic burden for communities in sub-Saharan Africa. The parasite that causes the disease is transmitted to the bloodstream of a human or ungulate via the tsetse… read more here.
Keywords: bloodstream; stage parasites; bromodomain; bromodomain proteins ... See more keywords
Use of a highly specific kinase inhibitor for rapid, simple and precise synchronization of Plasmodium falciparum and Plasmodium knowlesi asexual blood-stage parasites
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DOI: 10.1371/journal.pone.0235798
Abstract: During the course of the asexual erythrocytic stage of development, Plasmodium spp. parasites undergo a series of morphological changes and induce alterations in the host cell. At the end of this stage, the parasites egress… read more here.
Keywords: inhibitor; asexual blood; stage parasites; blood stage ... See more keywords