Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting Liver-Stage Plasmodium Infection
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DOI: 10.1128/aac.02218-21
Abstract: Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a potent multistage antimalarial activity. ABSTRACT Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a… read more here.
Keywords: plasmodium; stage plasmodium; liver stage; stage ... See more keywords
Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15031007
Abstract: The incidence rate of malaria and the ensuing mortality prompts the development of novel antimalarial drugs. In this work, the activity of twenty-eight Amaryllidaceae alkaloids (1–28) belonging to seven different structural types was assessed, as… read more here.
Keywords: hepatic stage; infection; stage plasmodium; stage ... See more keywords