Sulfonamide Prodrugs with a Two-Stage Release Mechanism for the Efficient Delivery of the TLR4 Antagonist TAK-242
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DOI: 10.1021/acsmedchemlett.2c00492
Abstract: We previously demonstrated that the potent TLR4 inhibitor TAK-242 could be covalently conjugated to pancreatic islets using a linker that afforded an effective sustained delivery of the active drug after transplant. This drug-eluting tissue achieved… read more here.
Keywords: two stage; release mechanism; stage release; tlr4 ... See more keywords