Sulfonamide Prodrugs with a Two-Stage Release Mechanism for the Efficient Delivery of the TLR4 Antagonist TAK-242
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00492
Abstract: We previously demonstrated that the potent TLR4 inhibitor TAK-242 could be covalently conjugated to pancreatic islets using a linker that afforded an effective sustained delivery of the active drug after transplant. This drug-eluting tissue achieved… read more here.
Keywords: two stage; release mechanism; stage release; tlr4 ... See more keywords
Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemistry"
DOI: 10.1038/s41557-024-01584-z
Abstract: Soft-matter nanoscale assemblies such as liposomes and lipid nanoparticles have the potential to deliver and release multiple cargos in an externally stimulated and site-specific manner. Such assemblies are currently structurally simplistic, comprising spherical capsules or… read more here.
Keywords: chemistry; release; stage release; synthesis ... See more keywords