Outcomes of Chemoimmunotherapy Among Patients With Extensive-Stage Small Cell Lung Cancer According to Potential Clinical Trial Eligibility
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.0698
Abstract: Key Points Question Can the outcomes of pivotal trials conducted among patients with extensive-stage small cell lung cancer (ES-SCLC) be applied in a clinical practice setting? Findings In this cohort study of 207 patients with… read more here.
Keywords: eligibility; trial; stage small; patients extensive ... See more keywords
Association of a Prophylactic Surgical Approach to Stage IV Small Intestinal Neuroendocrine Tumors With Survival
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.3326
Abstract: Importance Primary tumor resection and mesenteric lymph node dissection in asymptomatic patients with stage IV small intestinal neuroendocrine tumors (SI-NETs) are controversial. Objective To determine the association of locoregional surgery (LRS) performed at diagnosis with… read more here.
Keywords: surgery; small intestinal; treatment; stage small ... See more keywords
A pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited‐stage small cell lung cancer in elderly patients versus younger patients
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.31813
Abstract: Platinum and etoposide with thoracic radiation followed by prophylactic cranial irradiation constitute the standard treatment for limited‐stage small cell lung cancer (LS‐SCLC). Many patients with LS‐SCLC are elderly with comorbidities. read more here.
Keywords: limited stage; stage small; cell lung; clinical trials ... See more keywords
Adebrelimab versus serplulimab plus chemotherapy as first-line treatment for extensive-stage small-cell lung cancer: A cost-effectiveness analysis in China.
Sign Up to like & getrecommendations! Published in 2024 at "International journal of technology assessment in health care"
DOI: 10.1017/s0266462324000175
Abstract: Objective : We aimed to evaluate the cost-effectiveness of two first-line treatments newly approved 11 in the Chinese market for the treatment of extensive-stage small-cell lung cancer (ES-SCLC), 12 namely, adebrelimab plus chemotherapy (carboplatin+etoposide) and… read more here.
Keywords: plus chemotherapy; first line; treatment extensive; stage small ... See more keywords
Establishment of a prognostic nomogram for elderly patients with limited-stage small cell lung cancer receiving radiotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-62533-x
Abstract: The present study explored the risk factors associated with radiotherapy in seniors diagnosed with limited-stage small cell lung cancer (LS-SCLC) to construct and validate a prognostic nomogram. The study retrospectively included 137 elderly patients with… read more here.
Keywords: lung cancer; cell lung; small cell; cell ... See more keywords
Machine learning-based prediction model for brain metastasis in patients with extensive-stage small cell lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-80425-y
Abstract: Brain metastases (BMs) in extensive-stage small cell lung cancer (ES-SCLC) are often associated with poor survival rates and quality of life, making the timely identification of high-risk patients for BMs in ES-SCLC crucial. Patients diagnosed… read more here.
Keywords: brain; stage; model; extensive stage ... See more keywords
Comparison of efficacy and safety of first-line immunotherapy combined with chemotherapy in extensive-stage small cell lung cancer, a retrospective study
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DOI: 10.1038/s41598-025-23874-3
Abstract: Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis, in combination with platinum-based chemotherapy, have become the standard first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). Among these agents, serplulimab is a PD-1 inhibitor, while adebrelimab,… read more here.
Keywords: lung cancer; cell lung; small cell; extensive stage ... See more keywords
Navigating first-line therapies for extensive-stage small-cell lung cancer: a frequentist network meta-analysis and systematic review.
Sign Up to like & getrecommendations! Published in 2024 at "Future oncology"
DOI: 10.1080/14796694.2024.2376514
Abstract: Aim: To identify the optimal first-line treatment for patients with extensive-stage small-cell lung cancer (ES-SCLC). Materials & methods: We conducted a network meta-analysis (CRD42023486863) to systematically evaluate the efficacy and safety of eight first-line treatment… read more here.
Keywords: analysis; small cell; first line; extensive stage ... See more keywords
A simplified scoring system for predicting treatment response in limited-stage small-cell lung cancer (EAST score).
Sign Up to like & getrecommendations! Published in 2024 at "Future oncology"
DOI: 10.1080/14796694.2024.2444858
Abstract: AIMS This study aimed at developing a scoring system (EAST score) to predict recurrence after chemoradiotherapy in limited-stage small-cell lung cancer (LS-SCLC). PATIENTS & METHODS Treatment-naïve LS-SCLC patients receiving concurrent chemoradiotherapy (CCRT) (N = 234) or sequential… read more here.
Keywords: treatment; scoring system; risk; east score ... See more keywords
Prophylactic cranial irradiation for limited-stage small-cell lung cancer in the modern magnetic resonance imaging era may be omitted: a propensity score-matched analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrae087
Abstract: Abstract We aimed to clarify whether prophylactic cranial irradiation (PCI) is associated with improved outcomes in limited-stage small-cell lung cancer (LS-SCLC) in the current era of magnetic resonance imaging (MRI). Data from patients with LS-SCLC… read more here.
Keywords: cell lung; small cell; cranial irradiation; prophylactic cranial ... See more keywords
Impact of thoracic radiation therapy after chemotherapy on survival in extensive‐stage small cell lung cancer: A propensity score‐matched analysis
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.13001
Abstract: The role of thoracic radiation therapy (TRT) after chemotherapy (CHT) in extensive‐stage small cell lung cancer (ES‐SCLC) has not been well defined. We investigated whether intensity‐modulated radiotherapy (IMRT) improves outcomes in ES‐SCLC after CHT compared… read more here.
Keywords: radiation therapy; stage small; thoracic radiation; extensive stage ... See more keywords