Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09706-0
Abstract: Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader… read more here.
Keywords: stalk cell; tip stalk; angiogenesis; sprouting angiogenesis ... See more keywords
βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28933-1
Abstract: Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus highlighting the need for greater understanding of the vast crosstalk and compensatory mechanisms. Based on proteomic profiling of… read more here.
Keywords: regulator; stalk cell; spectrin stalk; cell ... See more keywords