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   Articles with "stalled replication" as a keyword



Dynamics of the Interaction of RecG Protein with Stalled Replication Forks.

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.7b01235

Abstract: As a guardian of the bacterial genome, the RecG DNA helicase repairs DNA replication and rescues stalled replication. We applied atomic force microscopy (AFM) to directly visualize dynamics of RecG upon the interaction with replication… read more here.

Keywords: stalled replication; replication forks; interaction recg; recg ... See more keywords

Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09196-9

Abstract: Stabilisation of stalled replication forks prevents excessive fork reversal and their pathological degradation, which can undermine genome integrity. Here we investigate a physiological role of RAD52 at stalled replication forks by using human cell models… read more here.

Keywords: degradation; fork; prevents excessive; stalled replication ... See more keywords
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SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-19162-5

Abstract: Protecting replication fork integrity during DNA replication is essential for maintaining genome stability. Here, we report that SDE2, a PCNA-associated protein, plays a key role in maintaining active replication and counteracting replication stress by regulating… read more here.

Keywords: sde2 integrates; fork; replication forks; tim ... See more keywords

ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2203783119

Abstract: Significance ASPM (encoded by MCPH5) is a frequently mutated protein, and such mutations occur in >40% of cases of primary microcephaly (MCPH). Here, we characterize a function of ASPM in DNA replication and the replication… read more here.

Keywords: atr chk1; stalled replication; replication; replication stress ... See more keywords

Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad186

Abstract: Genome duplication occurs while the template DNA is bound by numerous DNA-binding proteins. Each of these proteins act as potential roadblocks to the replication fork and can have deleterious effects on cells. In Escherichia coli,… read more here.

Keywords: dna; rep; rescue; stalled replication ... See more keywords

The PIN1–p38–CtIP signalling axis protects stalled replication forks from deleterious degradation

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf278

Abstract: Abstract Human CtIP plays a critical role in homologous recombination (HR) by promoting the resection of DNA double-strand breaks. Moreover, CtIP maintains genome stability through protecting stalled replication forks from nucleolytic degradation. However, the upstream… read more here.

Keywords: p38; stalled replication; pin1 p38; ctip ... See more keywords

PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx1298

Abstract: Abstract The DNA-dependent protein kinase (DNA-PK), consisting of the DNA binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs, has been well characterized in the non-homologous end-joining mechanism for DNA double strand break (DSB) repair and… read more here.

Keywords: stalled replication; signaling pathway; dna pkcs; dna ... See more keywords

Stn1 supports Mec1 function in protecting stalled replication forks from degradation

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recommendations! Published in 2025 at "PLOS Genetics"

DOI: 10.1371/journal.pgen.1011917

Abstract: Replication stress threatens genome integrity by exposing replication forks to nucleolytic degradation. In both yeast and humans, the checkpoint kinases Mec1 and Rad53 limit deleterious single-stranded DNA (ssDNA), yet the protective mechanisms remain incompletely defined.… read more here.

Keywords: replication; mec1; function; replication forks ... See more keywords