Detecting and Rescuing Stalled Ribosomes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2021.03.008
Abstract: Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that rescue stalled ribosomes must selectively detect rare aberrant translational complexes and process the heterogeneous components.… read more here.
Keywords: rescuing stalled; stalled ribosomes; detecting rescuing;
Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0022-5
Abstract: Ribosomal surveillance pathways scan for ribosomes that are transiently paused or terminally stalled owing to structural elements in mRNAs or nascent chain sequences1, 2. Some stalls in budding yeast are sensed by the GTPase Hbs1,… read more here.
Keywords: nascent chains; trna hydrolase; stalled ribosomes; peptidyl trna ... See more keywords