Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma
Sign Up to like & getrecommendations! Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2022.101368
Abstract: Highlights • A novel pair of orthotopic PDX models of glioma bearing IDH1-R132H/R132C mutations.• New mutant IDH1i (SY-435) with standard therapy led to strong therapeutic efficacy.• H3K4/K9 methylation/mtDNA-encoded molecules mediate anti-tumor activity of SYC-435.• Discovered… read more here.
Keywords: 435 standard; syc 435; models glioma; standard therapy ... See more keywords
Inhibition of Toxoplasma gondii by 1,2,4-triazole-based compounds: marked improvement in selectivity relative to the standard therapy pyrimethamine and sulfadiazine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2112576
Abstract: Abstract A safer treatment for toxoplasmosis would be achieved by improving the selectivity profile of novel chemotherapeutics compared to the standard therapy pyrimethamine (PYR) and sulfadiazine (SDZ). We previously reported on the identification of the… read more here.
Keywords: therapy pyrimethamine; toxoplasma; standard therapy; toxoplasma gondii ... See more keywords
665: IMPACT OF PHARMACIST INTERVENTION WITH PROCALCITONIN-GUIDED THERAPY IN ICU PATIENTS WITH PNEUMONIA
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000528680.68587.92
Abstract: Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Procalcitonin (PCT) is a peptide that is released in response to bacterial infections. The 2016 IDSA pneumonia guidelines recommend PCT to help… read more here.
Keywords: intervention; medicine; group; standard therapy ... See more keywords
Control of blood glucose levels by an artificial pancreas in patients with severe coronavirus disease 2019 pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Artificial Organs"
DOI: 10.1111/aor.14472
Abstract: Abstract Background Many patients with severe coronavirus disease 2019 (COVID‐19) pneumonia experience hyperglycemia. It is often difficult to control blood glucose (BG) levels in such patients using standard intravenous insulin infusion therapy. Therefore, we used… read more here.
Keywords: coronavirus disease; severe coronavirus; patients severe; therapy ... See more keywords
Osimertinib Is More Effective than Standard Therapy in EGFRT790M Tumors.
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DOI: 10.1158/2159-8290.cd-rw2017-040
Abstract: Osimertinib achieved better responses than platinum-pemetrexed in patients with EGFRT790M lung cancer. read more here.
Keywords: effective standard; standard therapy; egfrt790m tumors; therapy egfrt790m ... See more keywords
Thrombotic Events in COVID-19 Patients Undergoing Convalescent Plasma Therapy: A Systematic Review
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DOI: 10.1182/blood-2021-153374
Abstract: INTRODUCTION Convalescent plasma therapy (CPT) has been proposed as a mechanism of passive immunization against COVID-19. Current guidelines on the efficacy of its use is not well delineated with limited studies analyzing the risk of… read more here.
Keywords: review; risk; thrombotic events; therapy ... See more keywords
Total neoadjuvant therapy versus standard therapy in locally advanced rectal cancer: A systematic review and meta-analysis of 15 trials
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DOI: 10.1371/journal.pone.0276599
Abstract: Background Neoadjuvant chemoradiotherapy (nCRT) before total mesorectal excision (TME) and followed systemic chemotherapy is widely accepted as the standard therapy for locally advanced rectal cancer (LARC). This meta-analysis was to evaluate the current evidence regarding… read more here.
Keywords: standard therapy; rectal cancer; meta analysis; therapy ... See more keywords
Edoxaban (LIXIANA®) in the treatment of venous thromboembolism.
Sign Up to like & getrecommendations! Published in 2020 at "Future cardiology"
DOI: 10.2217/fca-2020-0139
Abstract: Standard therapy for venous thromboembolism (VTE) includes the use of heparins and vitamin K antagonists. Randomized clinical trials have shown that non-vitamin K oral anticoagulants are as effective and safe as standard therapy in VTE treatment,… read more here.
Keywords: venous thromboembolism; treatment; edoxaban lixiana; standard therapy ... See more keywords
Influence of adding strain-counterstrain to standard therapy on axioscapular muscles amplitude and fatigue in mechanical neck pain: a single-blind, randomized trial
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DOI: 10.23736/s1973-9087.22.07194-5
Abstract: BACKGROUND Strain-counterstrain technique (SCS) or positional release therapy is strongly recommended for patients with mechanical neck pain (MNP) because this method has excellent benefits, but the clinical significance of this method is unclear AIM The… read more here.
Keywords: neck pain; mechanical neck; therapy; pain ... See more keywords
Cost-effectiveness analysis of adding omega-3 or vitamin D supplementation to standard therapy in treating painful crises of pediatric sickle cell disease patients.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202210_30021
Abstract: OBJECTIVE Painful crises represents a predominant complication of sickle cell disease (SCD). The only approved treatments for painful crises in many countries are hydroxyurea plus potent analgesics. Our earlier clinical trial concluded that omega-3 and… read more here.
Keywords: cost; omega vitamin; standard therapy; painful crises ... See more keywords
Challenges and Perspectives of Standard Therapy and Drug Development in High-Grade Gliomas
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DOI: 10.3390/molecules26041169
Abstract: Despite their low incidence rate globally, high-grade gliomas (HGG) remain a fatal primary brain tumor. The recommended therapy often is incapable of resecting the tumor entirely and exclusively targeting the tumor leads to tumor recurrence… read more here.
Keywords: grade gliomas; high grade; standard therapy; tumor ... See more keywords