Adjunctive Rifampin Following Debridement and Implant Retention for Staphylococcal Prosthetic Joint Infection: Is it Effective if not Combined With a Fluoroquinolone?
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DOI: 10.1093/ofid/ofac582
Abstract: Abstract Whether rifampin benefits retained staphylococcal prosthetic joint infection is unsettled. In a meta-analysis of 8 studies, we found greater clinical cure with fluoroquinolone-rifampin vs all other regimens (odds ratio [OR], 2.68; 95% CI, 1.43–5.02),… read more here.
Keywords: staphylococcal prosthetic; prosthetic joint; joint infection; rifampin ... See more keywords
Deconstructing the Dogma: Systematic Literature Review and Meta-analysis of Adjunctive Gentamicin and Rifampin in Staphylococcal Prosthetic Valve Endocarditis
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DOI: 10.1093/ofid/ofac583
Abstract: Abstract Background Based primarily on in vitro and animal models, with little data directly addressing patient outcomes, current guidelines recommend treating staphylococcal prosthetic valve endocarditis (PVE) with antibiotic combinations including gentamicin and rifampin. Here, we… read more here.
Keywords: staphylococcal prosthetic; prosthetic valve; pve; rifampin ... See more keywords