The pearl necklace model in protein A chromatography: Molecular mechanisms at the resin interface
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26843
Abstract: Staphylococcal protein A chromatography is an established core technology for monoclonal antibody purification and capture in the downstream processing. MabSelect SuRe involves a tetrameric chain of a recombinant form of the B domain of staphylococcal… read more here.
Keywords: protein; staphylococcal protein; antibody; protein chromatography ... See more keywords
Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2016772118
Abstract: Significance Antibodies are crucial for the immune response against bacteria. To drive bacterial killing, antibodies should bind to the bacterial cell and induce the complement reaction. This requires target-bound IgGs to form hexameric IgG platforms… read more here.
Keywords: hexamerization; complement activation; activation; staphylococcal protein ... See more keywords
Characterization of SCCmec Instability in Methicillin-Resistant Staphylococcus aureus Affecting Adjacent Chromosomal Regions, Including the Gene for Staphylococcal Protein A (spa)
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02374-21
Abstract: Staphylococcal cassette chromosome mec (SCCmec) represents a sequence of clear clinical and diagnostic importance in staphylococci. At a minimum the chromosomal cassette contains the mecA gene encoding PBP2a but frequently also includes additional antibiotic resistance… read more here.
Keywords: cassette; staphylococcal protein; methicillin resistant; sccmec ... See more keywords
Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00899-21
Abstract: Staphylococcus aureus is one of the largest health care threats faced by humankind, with a reported mortality rate within the United States greater than that of HIV/AIDS, tuberculosis, and viral hepatitis combined. One of the… read more here.
Keywords: spa; staphylococcal protein; complexing human; necrosis ... See more keywords
Rapid Point-of-Care Tests Using Staphylococcal Protein A Can Detect Early IgM Responses in HIV-1 and Treponema pallidum Infections
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03309-22
Abstract: Sexually transmitted infections, including HIV and syphilis, remain a global public health concern. The main laboratory testing approach for HIV and syphilis relies on serological assays. ABSTRACT Serological assays detecting IgM antibodies in addition to… read more here.
Keywords: staphylococcal protein; hiv; igm; hiv syphilis ... See more keywords
Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A: Resolving the B-Cell Superantigen Paradox
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02011
Abstract: Staphylococcus aureus is a common commensal and frequent opportunistic pathogen that causes invasive infections that often recur. Co-evolution with the host has led to the development of toxins that affect diverse immune cell types. Recent… read more here.
Keywords: staphylococcal protein; superantigen properties; cell superantigen; cell ... See more keywords
Natural Human Immunity Against Staphylococcal Protein A Relies on Effector Functions Triggered by IgG3
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.834711
Abstract: Staphylococcal protein A (SpA) is a multifunctional, highly conserved virulence factor of Staphylococcus aureus. By binding the Fc portion of all human IgG subclasses apart from IgG3, SpA interferes with antibody and complement deposition on… read more here.
Keywords: natural human; staphylococcal protein; phagocytosis; spa ... See more keywords