Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display.
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DOI: 10.1021/acschembio.3c00048
Abstract: There are a wealth of proteins involved in disease that cannot be targeted by current therapeutics because they are inside cells, inaccessible to most macromolecules, and lack small-molecule binding pockets. Stapled peptides, where two amino… read more here.
Keywords: speed; evaluation staple; rapid evaluation; chemistry ... See more keywords