Stapled Helical Peptides Bearing Different Anchoring Residues.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.0c00532
Abstract: A large proportion of protein-protein interactions (PPIs) occur between a short peptide and a globular protein domain; the peptides involved in surface interactions play important roles, and there is great promise for using peptide motifs… read more here.
Keywords: helical peptides; protein interactions; different anchoring; anchoring residues ... See more keywords
High-Throughput Screening of Stapled Helical Peptides in Drug Discovery.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01541
Abstract: Therapeutic peptides have revolutionized treatment for a number of human diseases. In particular, the past two decades have witnessed rapid progress of stapled helical peptides in drug discovery. Stapled helical peptides are chemically modified and… read more here.
Keywords: drug discovery; stapled helical; helical peptides; throughput screening ... See more keywords
Directional assembly of a stapled α-helical peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04591k
Abstract: The de novo design of stapled peptide-based self-assemblies attracts vast interest, yet still remains challenging. The development of an oxidation trigger for peptide stapling and subsequent self-assembly is described here. A self-assembling sequence, Fmoc-R(RCEX)2-NH2, transformed… read more here.
Keywords: directional assembly; helical peptide; assembly stapled; self ... See more keywords