Pharmacogenetic analysis of structural variation in the 1000 genomes project using whole genome sequences
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-73748-3
Abstract: While significant strides have been made in understanding pharmacogenetics (PGx) and gene-drug interactions, there remains limited characterization of population-level PGx variation. This study aims to comprehensively profile global star alleles (haplotype patterns) and phenotype frequencies… read more here.
Keywords: star alleles; star; 1000 genomes; variation ... See more keywords
Contradiction in Star-Allele Nomenclature of Pharmacogenes between Common Haplotypes and Rare Variants
Sign Up to like & getrecommendations! Published in 2024 at "Genes"
DOI: 10.3390/genes15040521
Abstract: The nomenclature of star alleles has been widely used in pharmacogenomics to enhance treatment outcomes, predict drug response variability, and reduce adverse reactions. However, the discovery of numerous rare functional variants through genome sequencing introduces… read more here.
Keywords: star alleles; star allele; star; functional variants ... See more keywords