106 Randel Lecture: The history of the discovery of the Steroidogenic Acute Regulatory (StAR) Protein
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Animal Science"
DOI: 10.1093/jas/skz053.088
Abstract: This two-part presentation regarding acute regulation of steroid biosynthesis documents discovery of the StAR protein and resolves controversy regarding mitochondrial cholesterol transport. The acute regulation of steroid biosynthesis was known to require de novo synthesis… read more here.
Keywords: tspo; cholesterol; biosynthesis; star protein ... See more keywords
Knowledge Gap in Understanding the Steroidogenic Acute Regulatory Protein Regulation in Steroidogenesis Following Exposure to Bisphenol A and Its Analogues
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DOI: 10.3390/biomedicines10061281
Abstract: The use of bisphenols has become extremely common in our daily lives. Due to the extensive toxic effects of Bisphenol A (BPA), the industry has replaced this endocrine-disrupting chemical (EDC) with its analogues, which have… read more here.
Keywords: steroidogenesis; star protein; bpa analogues; regulation ... See more keywords
Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells
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DOI: 10.3390/ijms23073997
Abstract: Within Leydig cells, steroidogenesis is induced by the pituitary luteinizing hormone (LH). The binding of LH to its receptor increases cAMP production, which then activates the expression of genes involved in testosterone biosynthesis. One of… read more here.
Keywords: leydig cells; mixture; hormone; star protein ... See more keywords