Functional Definition of Thyroid Hormone Response Elements Based on a Synthetic STARR-seq Screen
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1101/2022.02.23.481571
Abstract: When bound to thyroid hormone, the nuclear receptor TRĪ±1 activates the transcription of a number of genes in many cell types. It mainly acts by binding DNA as an heterodimer with RXRs at specific response… read more here.
Keywords: response elements; thyroid hormone; starr seq; hormone response ... See more keywords
Correcting signal biases and detecting regulatory elements in STARR-seq data.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.269209.120
Abstract: High-throughput reporter assays such as self-transcribing active regulatory region sequencing (STARR-seq) have made it possible to measure regulatory element activity across the entire human genome at once. The resulting data, however, present substantial analytical challenges.… read more here.
Keywords: correcting signal; signal biases; biases detecting; seq data ... See more keywords