Arrangements of nucleotides flanking the start codon in the IRES of the hepatitis C virus in the IRES binary complex with the human 40S ribosomal subunit.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.02.016
Abstract: Genomic RNA of hepatitis C virus (HCV) has an internal ribosome entry site (IRES), a specific highly structured fragment responsible for its non-canonical translation initiation. The HCV IRES contains a major part of the 5'-untranslated… read more here.
Keywords: 40s ribosomal; start codon; binary complex; site ... See more keywords
Increased expression of the fluorescent reporter protein ymNeonGreen in Saccharomyces cerevisiae by reducing RNA secondary structure near the start codon.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Reports"
DOI: 10.1016/j.btre.2021.e00697
Abstract: Highlights • Stable secondary RNA structure 3′ of the start codon inhibits ymNeonGreen expression.• Removing secondary RNA structure increased expression in S. cerevisiae and E. coli.• Expression was increased 2-fold in S. cerevisiae.• Expression was… read more here.
Keywords: fluorescent reporter; expression; start codon; increased expression ... See more keywords
Role of aIF1 in Pyrococcus abyssi translation initiation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky850
Abstract: Abstract In archaeal translation initiation, a preinitiation complex (PIC) made up of aIF1, aIF1A, the ternary complex (TC, e/aIF2-GTP-Met-tRNAiMet) and mRNA bound to the small ribosomal subunit is responsible for start codon selection. Many archaeal… read more here.
Keywords: initiation; start codon; pyrococcus abyssi; aif1 ... See more keywords
A novel MBTPS2 start codon mutation causes a mild ichthyosis follicularis with atrichia and photophobia phenotype
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.14114
Abstract: Ichthyosis follicularis with atrichia and photophobia (IFAP; MIM 308205) syndrome is a rare, X-linked, oculocutaneous human disorder, which is caused by mutations in the gene MBTPS2. We report a Chinese family with one affected child,… read more here.
Keywords: phenotype; dermatology; start codon; ifap ... See more keywords
Translational recoding by chemical modification of non-AUG start codon ribonucleotide bases.
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DOI: 10.1126/sciadv.abm8501
Abstract: In contrast to prokaryotes wherein GUG and UUG are permissive start codons, initiation frequencies from non-AUG codons are generally low in eukaryotes, with CUG being considered as strongest. Here, we report that combined 5-cytosine methylation… read more here.
Keywords: start codon; chemical; non aug; aug start ... See more keywords
Development and characterisation of a chronic hepatitis B murine model with a mutation in the START codon of an HBV polymerase.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological research"
DOI: 10.33549/physiolres.934979
Abstract: Chronic hepatitis B (CHB) is caused by the Hepatitis B virus (HBV) and affects millions of people worldwide. Developing an effective CHB therapy requires using in vivo screening methods, such as mouse models reflecting CHB… read more here.
Keywords: mutation start; hbv; chronic hepatitis; start codon ... See more keywords
How Many Messenger RNAs Can Be Translated by the START Mechanism?
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DOI: 10.3390/ijms21218373
Abstract: Translation initiation is a key step in the protein synthesis stage of the gene expression pathway of all living cells. In this important process, ribosomes have to accurately find the AUG start codon in order… read more here.
Keywords: start mechanism; start; stable structures; start codon ... See more keywords