A human minisatellite hosts an alternative transcription start site for NPRL3 driving its expression in a repeat number‐dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Human Mutation"
DOI: 10.1002/humu.23974
Abstract: Minisatellites, also called variable number of tandem repeats (VNTRs), are a class of repetitive elements that may affect gene expression at multiple levels and have been correlated to disease. Their identification and role as expression… read more here.
Keywords: start site; number; repeat number; expression ... See more keywords
Chd1p recognizes H3K36Ac to maintain nucleosome positioning near the transcription start site.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.025
Abstract: In Saccharomyces cerevisiae, the ATP-dependent chromatin remodeler, Chd1p, globally affects nucleosome positioning at coding regions, where nucleosomes are specifically and directionally aligned with respect to the transcription start site (TSS). Various auxiliary domains of remodelers… read more here.
Keywords: start site; chd1p; h3k36ac; transcription start ... See more keywords
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109934
Abstract: Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of both FXR1 mRNA and protein. FXR1 expression directly associates with the survival and… read more here.
Keywords: start site; translation start; protein fxr1; translation ... See more keywords
Transcription start site signal profiling improves transposable element RNA expression analysis at locus-level
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1026847
Abstract: The transcriptional activity of Transposable Elements (TEs) has been involved in numerous pathological processes, including neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The TE expression analysis from short-read sequencing technologies is,… read more here.
Keywords: level; expression analysis; expression; transcription start ... See more keywords