Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00551
Abstract: Daunorubicin is a type II polyketide, one of a large class of polyaromatic natural products with anticancer, antibiotic, and antiviral activity. Type II polyketides are formed by the assembly of malonyl-CoA building blocks, though in… read more here.
Keywords: dpsc; studies daunorubicin; functional studies; structural functional ... See more keywords
Depside Bond Formation by the Starter-Unit Acyltransferase Domain of a Fungal Polyketide Synthase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08585
Abstract: Depsides are polyphenolic molecules comprising two or more phenolic acid derivatives linked by an ester bond, which is called a depside bond in these molecules. Despite more than a century of intensive research on depsides,… read more here.
Keywords: polyketide synthase; bond formation; depside bond; starter unit ... See more keywords