Novel chemical starting points for drug discovery in leishmaniasis and Chagas disease
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2019.05.002
Abstract: Visceral leishmaniasis (VL) and Chagas disease (CD) are caused by kinetoplastid parasites that affect millions of people worldwide and impart a heavy burden against human health. Due to the partial efficacy and toxicity-related limitations of… read more here.
Keywords: starting points; drug; leishmaniasis chagas; drug discovery ... See more keywords
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00510e
Abstract: Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling. As the biological functions of individual kinases become better understood, they can become targets of… read more here.
Keywords: nek family; kinase; starting points; chemical starting ... See more keywords
Using deep learning to automatically generate design starting points for free-form imaging optical systems.
Sign Up to like & getrecommendations! Published in 2022 at "Applied optics"
DOI: 10.1364/ao.460977
Abstract: In this paper, we propose a method to automatically generate design starting points for free-form three-mirror imaging systems with different folding configurations using deep neural networks. For a given range of system parameters, a large… read more here.
Keywords: starting points; design starting; free form; design ... See more keywords
Automatic design method of starting points of freeform off-axis reflective imaging systems of small volume.
Sign Up to like & getrecommendations! Published in 2022 at "Optics express"
DOI: 10.1364/oe.451511
Abstract: For off-axis reflective systems, there is no effective method that can obtain a small-volume starting point automatically. Reducing system volume using the optimization method is usually a difficult and cumbersome process, which usually takes the… read more here.
Keywords: starting points; volume; axis reflective; small volume ... See more keywords
Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273332
Abstract: In Germany, the incidence of cervical cancer, a disease caused by human papillomaviruses (HPV), is higher than in neighboring European countries. HPV vaccination has been recommended for girls since 2007. However, it continues to be… read more here.
Keywords: starting points; vaccination rates; vaccination; saarland ... See more keywords