JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1110765
Abstract: Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing studies show that the JAK/STAT pathway regulates the downstream signaling of numerous… read more here.
Keywords: jak; stat pathways; stat pathway; pathway extracellular ... See more keywords
An overview of JAK/STAT pathways and JAK inhibition in alopecia areata
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.955035
Abstract: Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair loss ranging from patches on the scalp to complete hair loss involving the entire body. Disease onset is hypothesized to follow the collapse… read more here.
Keywords: jak stat; disease; jak; hair ... See more keywords
Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.566148
Abstract: Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial… read more here.
Keywords: hearing loss; tlr stat; pioglitazone; organ corti ... See more keywords
The effect of valproic acid on intrinsic, extrinsic, and JAK/STAT pathways in neuroblastoma and glioblastoma cell lines
Sign Up to like & getrecommendations! Published in 2022 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.350240
Abstract: Background and purpose: Epigenetics has been defined as the study of mitotically heritable alterations in gene expression that are not caused by changes in DNA sequence. Epigenetic-mediated silencing of a gene includes genomic imprinting, histone… read more here.
Keywords: cell; neuroblastoma glioblastoma; expression; stat pathways ... See more keywords