Transcriptional and physiological roles for STAT proteins in leptin action
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.01.007
Abstract: Objectives Leptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal transducers and activators of transcription (STATs, including STAT1, STAT3, and… read more here.
Keywords: leprb neurons; leptin action; stat proteins; roles stat ... See more keywords
Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s93797
Abstract: Two immortalized human juvenile chondrocyte cell lines, T/C28a2 and C28/I2, were employed to determine the extent to which recombinant human (rh) IL-6, a known cytokine activator of the Janus kinase/signal transducers and activators of transcription… read more here.
Keywords: stat proteins; cell; phosphorylation; chondrocyte cell ... See more keywords
Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031564
Abstract: Uveal melanoma (UM) remains the most common intraocular malignancy among diseases affecting the adult eye. The primary tumor disseminates to the liver in half of patients and leads to a 6 to 12-month survival rate,… read more here.
Keywords: htr2b; expression; site; gene ... See more keywords
Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020240
Abstract: Signal Transducer and Activator of Transcription (STAT) proteins have been identified as drivers of prostate cancer (PCa) progression and development of aggressive castration-resistant phenotypes. In particular, STAT3, 5, and 6 have been linked to resistance… read more here.
Keywords: expression; influence; therapy; activity ... See more keywords